How Prolozone Therapy Works to Relieve Pain

Prolozone therapy treats pain by improving joint function and stability. Many dogs develop joint pain due to injury, aging, or chronic inflammation. When a joint becomes unstable, often due to ligament damage or overuse, capsular inflammation develops, triggering severe pain. Unlike some treatments that simply mask symptoms with drugs, prolozone addresses the source of the problem by stimulating healing and tissue regeneration.

This therapy uses a mild, controlled inflammatory response to stimulate mesodermal cell production. These cells help rebuild and strengthen the soft tissues supporting the joint, acting similarly to stem cell therapy. Each injection can tighten the joint by up to 22%, providing meaningful progress with each session. Over time, as joint stability increases, pain levels drop significantly, reducing or eliminating the need for other medications like NSAIDs or prescription pain medication.

Ideal Conditions for Pet Prolozone Therapy

We’ve seen excellent outcomes using pet prolozone therapy for a variety of joint-related issues. Dogs with knee injuries such as anterior cruciate ligament (ACL) tears, patellar luxation, or chronic arthritis tend to respond especially well. Hips, shoulders, and wrists also show good results, while elbows and backs can benefit if treated early. Whether your pet is dealing with acute pain or managing long-term joint health, this therapy may help improve comfort and function.

Dogs suffering from hip dysplasia, age-related degeneration, or previous injuries can experience noticeable improvements after just a few sessions. Each treatment is spaced several weeks apart, and most pets show significant relief after three to five appointments. Since prolozone also enhances blood flow and immune function, it supports overall healing and complements other therapies, such as mild exercise, fish oil supplements, physical therapy, and natural supplements for joint support.

Why Choose Prolozone Over NSAIDs and Other Drugs

Many pet owners seek alternative therapies when their dog can no longer tolerate traditional pain medication. NSAIDs, while effective in the short term, are known to cause worse side effects over time, especially in pets with liver disease, kidney failure, or pre-existing digestive issues. In some cases, dogs may also be sensitive to common drugs like ibuprofen, leading to serious complications such as gastric ulcers or organ damage.

Prolozone therapy offers a solution that reduces inflammation naturally without burdening the liver or kidneys. This makes it an ideal choice for pets that cannot safely take other medications. It can also be used alongside joint supplements, fish oil, or food-based remedies to create a well-rounded, supportive approach to pain management. Our goal is always to treat pain effectively while keeping your dog comfortable and minimizing the risks associated with conventional drugs.

What to Expect from a Prolozone Treatment

During your pet’s appointment, we’ll begin with a full exam to identify the affected joint and assess the severity of the issue. Your dog is then given a short-acting, reversible sedative to keep them calm and still. The joint is injected with a mixture of procaine, dextrose, and other substances that promote joint healing, followed by a dose of ozone gas to stimulate repair. We may also include antibiotics as part of the procedure. The sedation is then reversed, and your pet typically wakes up within minutes.

The entire treatment takes 30 to 40 minutes from start to finish. Most dogs recover quickly and experience minimal discomfort afterward. You may notice improvements in mobility and behavior after the first session, although full results often take a few treatments. By using this technique under the care of professionals trained in veterinary medicine and veterinary science, you can feel confident that your pet is receiving safe, effective care.

Integrate Prolozone Therapy into Your Pet’s Treatment Plan

At Mountain View Animal Hospital and Holistic Pet Care, we believe in a holistic approach to veterinary medicine. That means using the most effective tools from both Western and alternative therapies to relieve pain and improve your pet’s quality of life. Prolozone therapy is just one part of a comprehensive pain management strategy that may also include physical therapy, mild exercise, dietary changes, and other treatments tailored to your dog’s unique needs.

If your dog is struggling with joint pain, recovering from surgery, or living with a chronic condition that affects mobility, prolozone therapy may be an ideal way to help them feel better, without relying entirely on medication. Whether your goal is to reduce dependence on pain medication, avoid the side effects of NSAIDs, or explore alternative therapies, we’re here to create a personalized treatment plan that supports long-term healing.

Let us help your pet move more freely and live pain-free. Reach out today to learn more about how prolozone therapy can fit into your pet’s overall wellness plan. To request an appointment, call us at (775) 853-6900 or use our contact form.

Pet Prolozone Therapy FAQ

Pet prolozone therapy is a non-surgical treatment that uses ozone therapy combined with healing injectables to relieve pain and improve joint stability. The process involves injecting a mixture of ozone gas and supportive substances like procaine and dextrose into the affected joint. This stimulates a mild, controlled inflammatory response, which activates the healing process, encourages connective tissue repair, and strengthens the joint over time. That’s how prolozone therapy works to treat the underlying cause of joint pain instead of just masking the symptoms.

Prolozone therapy is especially beneficial for dogs suffering from degenerative joint disease, arthritis, chronic inflammation, ligament injuries (such as ACL tears), and joint pain related to hip dysplasia or aging. It’s also helpful for pets recovering from surgery or dealing with mobility issues due to past injuries. The therapy helps stabilize the joints, promote healing, and improve overall comfort and function.

While NSAIDs are commonly used to manage pain, they can cause harmful side effects over time, especially in dogs with liver disease, kidney issues, or sensitive stomachs. Pet prolozone therapy offers a natural, drug-free alternative that doesn’t burden the organs. It helps relieve pain and inflammation while supporting tissue regeneration, making it ideal for pets who cannot safely tolerate conventional medications or for owners looking to reduce long-term reliance on drugs.

Ozone therapy works by stimulating circulation, reducing inflammation, and increasing oxygen delivery to damaged tissues. When injected into affected joints, ozone encourages a localized response that accelerates tissue repair and reduces discomfort. By enhancing the healing process naturally, ozone not only helps relieve pain but also promotes healing from within—without the toxic load of synthetic drugs.

During a pet prolozone therapy session, your dog will receive a mild, reversible sedative to keep them relaxed. The affected joint is then injected with a combination of healing agents and ozone therapy. The whole process takes about 30–40 minutes, and most dogs are up and moving shortly afterward. Some dogs show improvement after one treatment, but most need 3–5 sessions spaced a few weeks apart for lasting relief from joint pain and chronic inflammation.

Absolutely. At Mountain View Animal Hospital, we use pet prolozone therapy as part of a holistic treatment strategy. This may include physical therapy, joint supplements, fish oil, and dietary changes. Because prolozone helps promote healing and improve joint function naturally, it complements other therapies and may help reduce the need for medications—especially for pets with conditions like degenerative joint disease or complications related to liver disease.